Impaired Precursor B Cell Differentiation in Bruton’s Tyrosine Kinase-Deficient Mice
نویسندگان
چکیده
منابع مشابه
Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice.
Bruton's tyrosine kinase (Btk) is a cytoplasmic signaling molecule that is crucial for precursor (pre-B) cell differentiation in humans. In this study, we show that during the transition of large cycling to small resting pre-B cells in the mouse, Btk-deficient cells failed to efficiently modulate the expression of CD43, surrogate L chain, CD2, and CD25. In an analysis of the kinetics of pre-B c...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2002
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.168.6.2695